Quorum Sensing: A Non-conventional Target for Antibiotic Discovery
نویسندگان
چکیده
منابع مشابه
Non-antibiotic quorum sensing inhibitors acting against N-acyl homoserine lactone synthase as druggable target
N-acylhomoserine lactone (AHL)-based quorum sensing (QS) is important for the regulation of proteobacterial virulence determinants. Thus, the inhibition of AHL synthases offers non-antibiotics-based therapeutic potentials against QS-mediated bacterial infections. In this work, functional AHL synthases of Pseudomonas aeruginosa LasI and RhlI were heterologously expressed in an AHL-negative Esche...
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The purpose of the present Perspectives is to present a synopsis of the literature on bacterial "quorum sensing" as a background for the proposal that interference with this communication system offers potential targets for the design of novel antibiotic drugs. Quorum sensing is the recently discovered chemical communication system among bacteria (both Gram-positive and -negative). It is vital ...
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Acinetobacter is a Gram-negative coccobacillus that is strictly aerobic, nonmotile, catalase positive and oxidase negative. It is ubiquitous in nature, being found in soil and water. Members of the genus Acinetobacter have now clearly emerged as opportunistic nosocomial pathogens (Forster et al., 1998). Bacteremia, pneumonia, meningitis, urinary tract and surgical wound infections are the most ...
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ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2013
ISSN: 1934-578X,1555-9475
DOI: 10.1177/1934578x1300801030